Structure and function of kidney water channels
نویسندگان
چکیده
منابع مشابه
[Structure and function of water channels].
All aquaporins are efficient water transporters, while sustaining strict selectivity, even against protons, thereby maintaining the proton gradient across the cell membrane. Recently solved structures of these membrane channels have helped us to understand this remarkable property.
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The aquaporins (AQPs) are a family of small membrane-spanning proteins (monomer size approximately 30 kDa) that are expressed at plasma membranes in many cells types involved in fluid transport. This review is focused on the molecular structure and function of mammalian aquaporins. Basic features of aquaporin structure have been defined using mutagenesis, epitope tagging, and spectroscopic and ...
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Cardiac pacemaking is controlled by a mixed Na(+)/K(+) current named I(f), which is activated by hyperpolarized membrane potentials. Recently, a family of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels has been cloned. The members of this family exhibit the general features of I(f) channels. This review describes the molecular diversity of the HCN channel family and t...
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Recent advances in molecular biology have had a major impact on our understanding of the biophysical and molecular properties of ion channels. This review is focused on cardiac potassium channels which, in general, serve to control and limit cardiac excitability. Approximately 60 K+ channel subunits have been cloned to date. The (evolutionary) oldest potassium channel subunits consist of two tr...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1995
ISSN: 0085-2538
DOI: 10.1038/ki.1995.390